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Review
. 2011 Jun 3:8:269.
doi: 10.1186/1743-422X-8-269.

Oncogenic potential of Human Papillomavirus (HPV) and its relation with cervical cancer

Rabia Faridi  1 , Amreen Zahra, Khalida Khan, Muhammad Idrees
Affiliations
Review

Oncogenic potential of Human Papillomavirus (HPV) and its relation with cervical cancer

Rabia Faridi et al. Virol J. .

Abstract

Human Papillomavirus (HPV) is the most common cause of cervical cancer. Cervical cancer being the second most common cancer after lung cancer, affecting women of different age groups; has a prevalence of about 20% in young sexually active women. Among different types of HPV, HPV16 the major strain causing this cancer and is sexually transmitted had been unnoticed for decades. Keeping in mind the multiple risk factors related with cervical cancer such as early age sexual activities, teenage pregnancies, smoking, use of oral contraceptives, having multiple sex partners, hormone replacement therapies and various other unknown factors lead to the onset of the disease. Awareness for various diagnostic procedures such as Pap smears screening prove to be an effective way in eradicating the oncogenic potential of HPV.

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Figures

Figure 1
Figure 1
The figure shows the location of the major open reading frames which possess the ability to encode proteins and the long control regions which have the ability of transcription and replication control elements (Adapted from Molecular biologists for Oncologists.1996, 2nd edd., Editors "J.R.Yarnold, M.R.Stratton, T.J.McmMillan" publishers, Chapman and Hall).
See this image and copyright information in PMC

References

    1. Warren Levinson, editor. Review of Medical Microbiology and Immunology. 10. Mc GrawHill; 2008. pp. 270–275.
    1. Yarnold JR, Stratton MR, McmMillan TJ, editor. Molecular biologists for Oncologists. 2. Chapman and Hall; 1996. pp. 83–88.
    1. Khan S, Jaffer NN, Khan MN, Rai MA, Shafiq M, Ali A, Pervez S, Khan N, Aziz A, Ali SH. Human papillomavirus subtype 16 is common in Pakistaniwomen with cervical carcinoma. Int J Infect Dis. 2007;11:313–317. doi: 10.1016/j.ijid.2006.06.007. - DOI - PubMed
    1. Yasmeen A, Alachkar A, Dekhil H, Gambacorti-Passerini C, Al Moustafa AE. Locking Src/AblTyrosine Kinase activities regulate cell Differentiation and Invasion of Human cervical cancer cells expressing E6/E7 oncoproteins of High-risk HPV. J Oncol. 2010;2010:10. - PMC - PubMed
    1. Stone MK, Karem LK, Sternberg RM, McQuillan MG, Poon DA, Unger RA, Reeves CW. Seroprevalence of human papillomavirus type16 infection in the United States. J Infect Dis. 2002;186:1396–1402. doi: 10.1086/344354. - DOI - PubMed

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