Review
doi: 10.1016/0885-3924(90)90009-9.
Pharmacology of spinal opioids
- PMID: 2164071
- DOI: 10.1016/0885-3924(90)90009-9
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Review
Pharmacology of spinal opioids
J Pain Symptom Manage.
1990 Jun.
Free article
Abstract
This review presents the pharmacology of spinal opioid receptor systems which are primarily involved in pain processing. The major areas upon which we will focus are: the structure and cellular functioning of the opioid receptor systems; the physiologic effects induced by spinally administered opioids, particularly in pain modulation; and pharmacokinetic and dynamic considerations, with special attention to the problem of opioid tolerance development.
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