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Review
. 2011 Jun 7;21(11):R414-5.
doi: 10.1016/j.cub.2011.04.022.

KASH and SUN proteins

Daniel A Starr  1
Affiliations
Review

KASH and SUN proteins

Daniel A Starr. Curr Biol. .
No abstract available

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Figures

Figure 1
Figure 1. KASH and SUN proteins bridge the nuclear envelope
KASH proteins (blue) span the outer nuclear membrane (ONM). The cytoplasmic domains of KASH proteins interact with a variety of cytoskeletal components. SUN proteins (yellow and red; shown as a dimer) span the inner nuclear membrane (INM). The nucleoplasmic domains of SUN proteins interact with lamins or other structural components of the nucleus. SUN and KASH domains interact with one another in the perinuclear space to form the central link of a bridge that spans the nuclear envelope, connecting the cytoskeleton to the nucleoskeleton.
See this image and copyright information in PMC

References

    1. Chikashige Y, Tsutsumi C, Yamane M, Okamasa K, Haraguchi T, Hiraoka Y. Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes. Cell. 2006;125:59–69. - PubMed
    1. Crisp M, Liu Q, Roux K, Rattner JB, Shanahan C, Burke B, Stahl PD, Hodzic D. Coupling of the nucleus and cytoplasm: role of the LINC complex. J. Cell Biol. 2006;172:41–53. - PMC - PubMed
    1. Starr DA, Fridolfsson HN. Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges. Annu. Rev. Cell Dev. Biol. 2010;26:421–444. - PMC - PubMed
    1. Starr DA, Han M. Role of ANC-1 in tethering nuclei to the actin cytoskeleton. Science. 2002;298:406–409. - PubMed
    1. Zhang X, Lei K, Yuan X, Wu X, Zhuang Y, Xu T, Xu R, Han M. SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron. 2009;64:173–187. - PMC - PubMed

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