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. 2011 Jun 3;16(6):4642-51.
doi: 10.3390/molecules16064642.

Triterpenoids from the roots of Sanguisorba tenuifolia var. Alba

Hai-Xue Kuang  1 , Hong-Wei Li, Qiu-Hong Wang, Bing-You Yang, Zhi-Bin Wang, Yong-Gang Xia
Affiliations

Triterpenoids from the roots of Sanguisorba tenuifolia var. Alba

Hai-Xue Kuang et al. Molecules. .

Abstract

The ethyl acetate soluble fraction from the roots of Sanguisorba tenuifolia was found to have a hypoglucemic effect in alloxan-induced diabetic rats. Two new triterpenoids, identified as 2-oxo-3β,19α-dihydroxyolean-12-en-28-oic acid β-D-gluco-pyranosyl ester (1) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid β-D-glucopyranosyl ester (4) were isolated from this fraction, along with thirteen known triterpenoids. Their structures were elucidated by chemical and spectroscopic methods. All these compounds demonstrated inhibitory activities against α-glucosidase with IC₅₀ values in the 0.62-3.62 mM range.

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Figures

Figure 1
Figure 1
Structures of 1-15.
Figure 2
Figure 2
Key HMBC and 1H-1H COSY correlations of 1 and 4.
See this image and copyright information in PMC

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