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. 2011:5:49-63.
doi: 10.2174/1874192401105010049. Epub 2011 Feb 24.

HIV and HAART-Associated Dyslipidemia

Eoin R Feeney  1 , Patrick W G Mallon
Affiliations

HIV and HAART-Associated Dyslipidemia

Eoin R Feeney et al. Open Cardiovasc Med J. 2011.

Abstract

Effective highly active antiretroviral therapy (HAART) for human immunodeficiency virus-1 (HIV) infection has led to marked improvement in life-expectancy for those infected with HIV. Despite reductions in the incidence of AIDS with effective treatment, patients continue to experience considerable morbidity and mortality from non-AIDS illness such as premature cardiovascular disease, liver failure and renal failure. These morbidities, particularly premature cardiovascular disease, are thought to be related to a combination of the effects of an ageing HIV-infected population coupled with long-term effects of HIV infection and antiretroviral therapy (ART). One of the principle drivers behind the well documented increase in the risk of cardiovascular disease in HIV-infected patients is dyslipidemia.This review will focus on the clinical presentation of HIV and ART-associated dyslipidemia, what is known of its patho-physiology, including associations with use of specific antiretroviral medications, and suggest screening and management strategies.

Keywords: HAART; HIV; cholesterol; dyslipidemia; lipids.; triglycerides.

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Figures

Fig. (1)
Fig. (1)
Screening and treatment algorithm.
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