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Review
. 2011 Oct;66(10):1275-86.
doi: 10.1111/j.1398-9995.2011.02661.x. Epub 2011 Jun 7.

The in vitro diagnosis of drug allergy: status and perspectives

D G Ebo  1 , J Leysen, C Mayorga, A Rozieres, E F Knol, I Terreehorst
Affiliations
Review

The in vitro diagnosis of drug allergy: status and perspectives

D G Ebo et al. Allergy. 2011 Oct.

Abstract

Adverse drug reactions (ADR) can result from immune-mediated (drug allergy) and nonimmune-mediated mechanisms. In both types of reaction, conclusive diagnosis and appropriate management remain major problems in daily clinical practice. This review summarizes the potentials and shortcomings of the currently available in vitro tests in the diagnosis of immediate (mostly IgE mediated) and nonimmediate (mostly T-cell mediated) drug allergy, particularly quantification of specific IgE, flow-assisted analysis of in vitro activated lymphocytes and basophils and the enzyme-linked immunosorbent spot.

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