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. 1979 Feb;65(2):163-5.
doi: 10.1111/j.1476-5381.1979.tb07814.x.

Cyclic adenosine 3', 5'-monophosphate and the mechanism of action of three common anti-inflammatory drugs

D A Deporter, C J Dunn, D A Willoughby

Cyclic adenosine 3', 5'-monophosphate and the mechanism of action of three common anti-inflammatory drugs

D A Deporter et al. Br J Pharmacol. 1979 Feb.

Abstract

1 The effects of indomethacin, dexamethasone and colchicine on cyclic adenosine 3', 5'-monophosphate (cyclic AMP) concentration in leucocytes during a crystal-induced pleurisy in rats were studied. 2 Each of the drugs significantly increased leucocyte cyclic AMP content within 3 h of the injection of crystals. 3 By 6 h, leucocyte cyclic AMP levels returning toward control levels and could not be sustained at the higher level by an additional administration of the respective anti-inflammatory drug.

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References

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