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. 1990 Aug;64(8):4025-8.
doi: 10.1128/JVI.64.8.4025-4028.1990.

Activation of class I major histocompatibility complex gene expression by hepatitis B virus

D X Zhou  1 , A Taraboulos, J H Ou, T S Yen
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Activation of class I major histocompatibility complex gene expression by hepatitis B virus

D X Zhou et al. J Virol. 1990 Aug.

Abstract

Normal hepatocytes express very few class I major histocompatibility complex (MHC I) molecules, but MHC I expression is elevated in hepatitis B virus (HBV) infection. We report here that hepatoblastoma cells with replicating HBV genomes express three- to fourfold-higher levels of MHC I protein and mRNA than do parent cells without HBV DNA. Transient transfection assays demonstrated that the HBV X protein trans activated transcription from an MHC I promoter and allowed identification of cis elements important for trans activation.

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