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. 2011 Feb 24;3(1):e9.
doi: 10.4081/pr.2011.e9.

Preventing transmission of infectious agents in the pediatric in-patients hematology-oncology setting: what is the role for non-pharmacological prophylaxis?

Désirée Caselli  1 , Simone Cesaro, Susanna Livadiotti, Ottavio Ziino, Olivia Paolicchi, Giulio Zanazzo, Giuseppe M Milano, Maria Licciardello, Angelica Barone, Monica Cellini, De Santis Raffaella, Mareva Giacchino, Mario Renato Rossi, Maurizio Aricò, Elio Castagnola; Infection Study Group of the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP)
Affiliations

Preventing transmission of infectious agents in the pediatric in-patients hematology-oncology setting: what is the role for non-pharmacological prophylaxis?

Désirée Caselli et al. Pediatr Rep. .

Abstract

The most intensive chemotherapy regimens were used in the past for leukemia patients who were the main focus of trials on infections; today there are increasing numbers of children with solid cancer and considerable risk of infection who do receive intensive standard-dose chemotherapy. Despite a continuous will to protect the immune-compromised child from infections, evidence-based indications for intervention by non-pharmacological tools is still lacking in the pediatric hematology-oncology literature. Guidelines on standard precautions as well as precautions to avoid transmission of specific infectious agents are available. As a result of a consensus discussion, the Italian Association for Pediatric Hematology-Oncology (AIEOP) Cooperative Group centers agree that for children treated with chemotherapy both of these approaches should be implemented and vigorously enforced, while additional policies, including strict environmental isolation, should be restricted to patients with selected clinical conditions or complications. We present here a study by the working group on infectious diseases of AIEOP.

Keywords: chemotherapy; infections; leukemia; pediatrics..

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