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. 2011 Jun 7:11:226.
doi: 10.1186/1471-2407-11-226.

Neutrophilic airways inflammation in lung cancer: the role of exhaled LTB-4 and IL-8

Giovanna E Carpagnano  1 , Grazia P Palladino, Donato Lacedonia, Anna Koutelou, Silvio Orlando, Maria P Foschino-Barbaro
Affiliations

Neutrophilic airways inflammation in lung cancer: the role of exhaled LTB-4 and IL-8

Giovanna E Carpagnano et al. BMC Cancer. .

Abstract

Background: Recent advances in lung cancer biology presuppose its inflammatory origin. In this regard, LTB-4 and IL-8 are recognized to play a crucial role in neutrophil recruitment into airways during lung cancer.Notwithstanding the intriguing hypothesis, the exact role of neutrophilic inflammation in tumour biology remains complex and not completely known.The aim of this study was to give our contribution in this field by investigating LTB-4 and IL-8 in the breath condensate of NSCLC patients and verifying their role in cancer development and progression.

Method: We enrolled 50 NSCLC patients and 35 controls. LTB-4 and IL-8 concentrations were measured in the breath condensate and the blood of all the subjects under study using EIA kits. Thirty NSCLC patients and ten controls underwent induced sputum collection and analysis.

Results: LTB-4 and IL-8 resulted higher in breath condensate and the blood of NSCLC patients compared to controls. Significantly higher concentrations were found as the cancer stages progressed. A positive correlation was observed between exhaled IL-8 and LTB-4 and the percentage of neutrophils in the induced sputum.

Conclusion: The high concentrations of exhaled LTB-4 and IL-8 showed the presence of a neutrophilic inflammation in the airways of NSCLC patients and gave a further support to the inflammatory signalling in lung cancer. These exhaled proteins could represent a suitable non-invasive marker in the diagnosis and monitoring of lung cancer.

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Figures

Figure 1
Figure 1
LTB-4 (Panel A) and IL-8 (Panel B) levels were significantly higher in the EBC of NSCLC patients than in the EBC of control subjects (p < 0.001).
Figure 2
Figure 2
Progressively higher concentrations of LTB-4 (Panel A) and IL-8 (Panel B) in EBC were found from stage I to stage IV. Significant differences between each stage and the next one were observed (p < 0.005).
Figure 3
Figure 3
LTB-4 (Panel A) and IL-8 (Panel B) levels were significantly higher in the EBC of smokers compared to non smokers either in NSCLC or in healthy group (p < 0.001, p < 0.005).
See this image and copyright information in PMC

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