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Comparative Study
. 2011 Aug 4;118(5):1413-20.
doi: 10.1182/blood-2011-01-331835. Epub 2011 Jun 7.

Long-term health-related outcomes in survivors of childhood cancer treated with HSCT versus conventional therapy: a report from the Bone Marrow Transplant Survivor Study (BMTSS) and Childhood Cancer Survivor Study (CCSS)

Saro H Armenian  1 , Can-Lan Sun, Toana Kawashima, Mukta Arora, Wendy Leisenring, Charles A Sklar, K Scott Baker, Liton Francisco, Jennifer Berano Teh, George Mills, F Lennie Wong, Joseph Rosenthal, Lisa R Diller, Melissa M Hudson, Kevin C Oeffinger, Stephen J Forman, Leslie L Robison, Smita Bhatia
Affiliations
Comparative Study

Long-term health-related outcomes in survivors of childhood cancer treated with HSCT versus conventional therapy: a report from the Bone Marrow Transplant Survivor Study (BMTSS) and Childhood Cancer Survivor Study (CCSS)

Saro H Armenian et al. Blood. .

Abstract

HSCT is being increasingly offered as a curative option for children with hematologic malignancies. Although survival has improved, the long-term morbidity ascribed to the HSCT procedure is not known. We compared the risk of chronic health conditions and adverse health among children with cancer treated with HSCT with survivors treated conventionally, as well as with sibling controls. HSCT survivors were drawn from BMTSS (N = 145), whereas conventionally treated survivors (N = 7207) and siblings (N = 4020) were drawn from CCSS. Self-reported chronic conditions were graded with CTCAEv3.0. Fifty-nine percent of HSCT survivors reported ≥ 2 conditions, and 25.5% reported severe/life-threatening conditions. HSCT survivors were more likely than sibling controls to have severe/life-threatening (relative risk [RR] = 8.1, P < .01) and 2 or more (RR = 5.7, P < .01) conditions, as well as functional impairment (RR = 7.7, P < .01) and activity limitation (RR = 6.3, P < .01). More importantly, compared with CCSS survivors, BMTSS survivors demonstrated significantly elevated risks (severe/life-threatening conditions: RR = 3.9, P < .01; multiple conditions: RR = 2.6, P < .01; functional impairment: RR = 3.5, P < .01; activity limitation: RR = 5.8, P < .01). Unrelated donor HSCT recipients were at greatest risk. Childhood HSCT survivors carry a significantly greater burden of morbidity not only compared with noncancer populations but also compared with conventionally treated cancer patients, providing evidence for close monitoring of this high-risk population.

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Figures

Figure 1
Figure 1
Health-related outcomes. (A) Prevalence of chronic health conditions among HSCT survivors (BMTSS) compared with conventionally treated cancer survivors (CCSS) and sibling controls (CCSS). (B) Prevalence of adverse health status among HSCT survivors (BMTSS) compared with conventionally treated cancer survivors (CCSS) and sibling controls (CCSS).
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Comment in

  • Survivors after blood wars.
    Socié G. Socié G. Blood. 2011 Aug 4;118(5):1194-5. doi: 10.1182/blood-2011-06-361345. Blood. 2011. PMID: 21816841 No abstract available.

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