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. 2011 Jan;28(1):11-6.
doi: 10.4103/0970-2113.76294.

Clinico-epidemiological features of the hospitalized patients with 2009 pandemic influenza A (H1N1) virus infection in Saurashtra region, India (September, 2009 to February, 2010)

Rajesh K Chudasama  1 , Umed V Patel, Pramod B Verma, Chikitsa D Amin, Dinkar Savaria, Rakesh Ninama, Nilesh Fichadiya
Affiliations

Clinico-epidemiological features of the hospitalized patients with 2009 pandemic influenza A (H1N1) virus infection in Saurashtra region, India (September, 2009 to February, 2010)

Rajesh K Chudasama et al. Lung India. 2011 Jan.

Abstract

Background: The first case of 2009 pandemic influenza A (H1N1) virus infection in India was reported in May, 2009 and in Saurashtra region in August, 2009. We describe the clinico-epidemiological characteristics of patients who were hospitalized with 2009 influenza A (H1N1) infection in Saurashtra region.

Materials and methods: From September, 2009 to February, 2010, we observed 274 persons infected with 2009 influenza A (H1N1) virus who were admitted in different hospitals in Rajkot city. Real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) testing was used to confirm infection; the clinico-epidemiological features of the disease were closely monitored.

Results: Of 274 patients, median age was 29.5 years, and 51.5% were males. Only 1.1% patients had recent travel history to infected region. Median time of five days was observed from onset of illness to influenza A (H1N1) diagnosis, while median time of six days reported for hospital stay. All admitted patients received oseltamivir drug, but only 16.1% received it within two days of onset of illness. One fourth of admitted patients were expired. The most common symptoms were cough (96.7%), fever (92%), sore throat and shortness of breathing, and coexisting conditions including diabetes mellitus (9.9%), hypertension (8.8%), chronic pulmonary diseases (5.5%) and pregnancy (5.5%) (P<0.05). Pneumonia was reported in 93% patients with chest radiography.

Conclusion: We have demonstrated that infection-related illness affects both children and adults with survival of 74% patients. The median time from onset of illness to virus detection with use of real-time RT-PCR is five days. Pregnancy is found as a significant (P<0.05) risk factor for severe disease.

Keywords: Epidemiologic information; H1N1 subtype; influenza A virus; reverse transcriptase polymerase chain reaction.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Week wise distribution of infected influenza A (H1N1) cases from September 2009 to February 2010 in Saurashtra region
See this image and copyright information in PMC

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