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Case Reports
. 2011 Sep;7(3):213-9.
doi: 10.1007/s13181-011-0157-3.

Case files of the medical toxicology fellowship at Drexel University. Rhabdomyolysis and compartment syndrome following acute diphenhydramine overdose

David Vearrier  1 , John A Curtis
Affiliations
Case Reports

Case files of the medical toxicology fellowship at Drexel University. Rhabdomyolysis and compartment syndrome following acute diphenhydramine overdose

David Vearrier et al. J Med Toxicol. 2011 Sep.
No abstract available

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Figures

Fig. 1
Fig. 1
In the absence of stimulation, the Gq/11-coupled H1 receptor exerts a basal level of activity. H1-receptor ligands, therefore, may act as agonists, inverse agonists, or neutral antagonists. Full or partial agonists stabilize the active state resulting in increased receptor signaling, while full or partial inverse agonists stabilize the inactive state and decrease receptor signaling. Neutral antagonists bind the H1 receptor without modifying the basal level of activity, but competitively inhibit the binding of other agonists or inverse agonists. (Adapted with permission from Leurs et al. [2])
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References

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    1. Spector R, et al. Diphenhydramine in Orientals and Caucasians. Clin Pharmacol Ther. 1980;28(2):229–234. doi: 10.1038/clpt.1980.155. - DOI - PubMed
    1. Akutsu T, et al. Identification of human cytochrome P450 isozymes involved in diphenhydramine N-demethylation. Drug Metab Dispos. 2007;35(1):72–78. doi: 10.1124/dmd.106.012088. - DOI - PubMed
    1. Fischer D, Breyer-Pfaff U. Variability of diphenhydramine N-glucuronidation in healthy subjects. Eur J Drug Metab Pharmacokinet. 1997;22(2):151–154. doi: 10.1007/BF03189799. - DOI - PubMed

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