Comparison of selective laser trabeculoplasty success in patients treated with either prostaglandin or timolol/dorzolamide fixed combination

Abstract

Purpose: The purpose of this study was to compare the efficacy of selective laser trabeculoplasty (SLT) in eyes of patients with open-angle glaucoma receiving either a prostaglandin (PG) analog or a timolol/dorzolamide fixed combination (TDFC).

Methods: In this retrospective study, we analyzed 48 eyes of 35 patients who underwent SLT for open-angle glaucoma receiving either a PG analog (n=20) or a TDFC (n=28). Mean decrease in intraocular pressure (IOP) and success rates were compared between patients treated with PG and those treated with TDFC. Success was defined as an IOP reduction of at least 20% at postoperative 1 year.

Results: The mean decrease in IOP in eyes treated with PG and in eyes treated with TDFC were 4.1±3.1 and 4.6±3.5 at 1 week (P=0.579), 5.3±3.4 and 5.7±2.0 at 1 month (P=0.485), 5.2±3.1 and 5.5±2.5 at 3 months (P=0.271), 5.0±3.1 and 6.1±2.5 and at 6 months (P=0.044), and 4.7±3.1 and 6.5±2.9 at 1 year (P=0.017), respectively. The success rate at postoperative 1 year was 50.0% (standard deviation±16) in eyes receiving PG and 78.6% (standard deviation:±11) in eyes receiving TDFC (P=0.041).

Conclusion: This study shows that the SLT seems to be more effective in TDFC users than PG analog users.