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. 1990 Aug 10;62(3):527-38.
doi: 10.1016/0092-8674(90)90017-9.

A novel function of the transforming domain of E1a: repression of AP-1 activity

R Offringa  1 , S Gebel, H van Dam, M Timmers, A Smits, R Zwart, B Stein, J L Bos, A van der Eb, P Herrlich
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A novel function of the transforming domain of E1a: repression of AP-1 activity

R Offringa et al. Cell. .

Abstract

Adenovirus E1a represses transcription of the collagenase gene via the phorbol ester-responsive element (collTRE). The mechanism involves inhibition of the trans-activating function of the transcription factor AP-1 without reduction of its synthesis and without any apparent change in DNA binding or composition. The ability of E1a to downmodulate AP-1 is a unique property among dominant oncogenes. This repression depends on conserved region 1, one of the transforming domains of E1a, indicating that it is an integral feature of adenovirus transformation.

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