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. 2011:2011:858154.
doi: 10.1155/2011/858154. Epub 2011 May 24.

Patient characteristics in persistent pulmonary hypertension of the newborn

M T R Roofthooft  1 , A Elema, K A Bergman, R M F Berger
Affiliations

Patient characteristics in persistent pulmonary hypertension of the newborn

M T R Roofthooft et al. Pulm Med. 2011.

Abstract

Objective. To assess the impact of PPHN on mortality, morbidity, and behavioural skills. Methods. A retrospective observational study of 143 newborns with PPHN, over an 11-year period, using objective health-status data from medical records and family doctors, and subjective health status data from a standardized Child Behaviour Checklist. Results. The majority of patients were males, treated with inhaled nitric oxide had maladaptation/maldevelopment as pathophysiological mechanism and a gestational age >37 weeks. In term newborns, types of pathophysiological mechanism (P < .001) and Oxygen Index (P = .02) were independent predicting risk factors for PPHN-related mortality. Analysis of preexisting disease and outcome categories in term newborns showed only a significant correlation between the use of iNO and respiratory complaints (P = .03), not confirmed by multivariate analysis and regression analysis. Conclusions. PPHN is a serious, often fatal condition. The incidence of PPHN in preterm newborns is high. In term survivors, PPHN had no additional role in morbidity/outcome.

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