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. 1990 Mar-Apr;53(2):340-4.
doi: 10.1021/np50068a011.

A simplified plaque reduction assay for antiviral agents from plants. Demonstration of frequent occurrence of antiviral activity in higher plants

M Abou-Karam  1 , W T Shier
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A simplified plaque reduction assay for antiviral agents from plants. Demonstration of frequent occurrence of antiviral activity in higher plants

M Abou-Karam et al. J Nat Prod. 1990 Mar-Apr.

Abstract

An improved plaque reduction assay for antiviral activity was developed and used to examine extracts from sixty-one higher plants. Substantial antiviral activity was observed in ca. 20%, which is higher than might be expected given the limited metabolic differences between viruses and their hosts. The frequent antiviral activity may represent phytoalexins elaborated to protect against plant viruses.

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