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. 1978 Dec 18;45(2):203-7.
doi: 10.1007/BF00286964.

Appearance of hCG-receptor after conversion of newborn ovarian cells into testicular structures by H-Y antigen in vitro

U Müller, M T Zenzes, T Bauknecht, U Wolf, J W Siebers, W Engel

Appearance of hCG-receptor after conversion of newborn ovarian cells into testicular structures by H-Y antigen in vitro

U Müller et al. Hum Genet. .

Abstract

In a previous report (Zenzes et al., 1978b) it was shown that dissociated ovarian cells of newborn rats in vitro, if exposed to H-Y antigen, reorganize into testicular structures. The current study was designed to see whether this morphological conversion also results in a functional conversion. The LH/hCG receptor was used as a parameter characteristic for the newborn testis, but not for the newborn ovary. In the converted ovary, the LH/hCG receptor becomes detectable a few hours after onset of the culture and remains continuously present afterward. The appearance of this receptor may be due to a hormone-like action of H-Y antigen.

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