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Comment
. 2011 Jun 10;145(6):813-4.
doi: 10.1016/j.cell.2011.05.031.

Treating the periphery to ameliorate neurodegenerative diseases

Peter H Reinhart  1 , Jeffery W Kelly
Affiliations
Free article
Comment

Treating the periphery to ameliorate neurodegenerative diseases

Peter H Reinhart et al. Cell. .
Free article

Abstract

Abnormalities in the kynurenine pathway are associated with neurodegenerative disorders. Zwilling et al. (2011) show that inhibition of kynurenine 3-monooxygenase in the body's periphery leads to an increase in kyneuric acid, a neuroprotective compound, in the brain. This intervention ameliorates neurodegeneration in mouse models of Alzheimer's disease and Huntington's disease.

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  • Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.
    Zwilling D, Huang SY, Sathyasaikumar KV, Notarangelo FM, Guidetti P, Wu HQ, Lee J, Truong J, Andrews-Zwilling Y, Hsieh EW, Louie JY, Wu T, Scearce-Levie K, Patrick C, Adame A, Giorgini F, Moussaoui S, Laue G, Rassoulpour A, Flik G, Huang Y, Muchowski JM, Masliah E, Schwarcz R, Muchowski PJ. Zwilling D, et al. Cell. 2011 Jun 10;145(6):863-74. doi: 10.1016/j.cell.2011.05.020. Cell. 2011. PMID: 21640374 Free PMC article.

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