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Review
. 2011 Oct;13(11):888-94.
doi: 10.1016/j.micinf.2011.05.008. Epub 2011 May 30.

Autophagy facilitates an IFN-γ response and signal transduction

Yu-Ping Chang  1 , Chia-Ling Chen, Su-O Chen, Yee-Shin Lin, Cheng-Chieh Tsai, Wei-Ching Huang, Chi-Yun Wang, Chia-Yuan Hsieh, Pui-Ching Choi, Chiou-Feng Lin
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Free article
Review

Autophagy facilitates an IFN-γ response and signal transduction

Yu-Ping Chang et al. Microbes Infect. 2011 Oct.
Free article

Abstract

Autophagy, that is directly triggered by invaded pathogens and indirectly triggered by IFN-γ, acts as a defense by mediating intracellular microbial recognition and clearance. In addition, autophagy contributes to inflammation by facilitating an IFN-γ response and signal transduction. For immune escape, downregulated autophagy may be a strategy used by microbes.

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