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Review
. 2011 Jul;204 Suppl 1(Suppl 1):S47-53.
doi: 10.1093/infdis/jir065.

Biological feasibility of measles eradication

William J Moss  1 , Peter Strebel
Affiliations
Review

Biological feasibility of measles eradication

William J Moss et al. J Infect Dis. 2011 Jul.

Abstract

Recent progress in reducing global measles mortality has renewed interest in measles eradication. Three biological criteria are deemed important for disease eradication: (1) humans are the sole pathogen reservoir; (2) accurate diagnostic tests exist; and (3) an effective, practical intervention is available at reasonable cost. Interruption of transmission in large geographical areas for prolonged periods further supports the feasibility of eradication. Measles is thought by many experts to meet these criteria: no nonhuman reservoir is known to exist, accurate diagnostic tests are available, and attenuated measles vaccines are effective and immunogenic. Measles has been eliminated in large geographical areas, including the Americas. Measles eradication is biologically feasible. The challenges for measles eradication will be logistical, political, and financial.

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Figures

Figure 1.
Figure 1.
Box plots showing the proportion of children who respond to standard-titer measles vaccine by age at vaccination. Source: Moss WJ, Scott S. WHO Immunological Basis for Immunization Series: Measles.Geneva, Switzerland: World Health Organzation, 2009.
Figure 2.
Figure 2.
Estimated number of measles deaths worldwide, 2000–2008. Adapted from Weekly Epidemiological Record 2009;85:513.
See this image and copyright information in PMC

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