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Clinical Trial
. 1990 May;8(2):183-5.
doi: 10.1007/BF00177255.

Phase II study of n-methylformamide (NSC 3051) and spirogermanium (NSC 192965) in the treatment of advanced small cell lung cancer

D S Ettinger  1 , D M Finkelstein, M D Abeloff, Y C Chang, T J Smith, M M Oken, J C Ruckdeschel
Affiliations
Clinical Trial

Phase II study of n-methylformamide (NSC 3051) and spirogermanium (NSC 192965) in the treatment of advanced small cell lung cancer

D S Ettinger et al. Invest New Drugs. 1990 May.

Abstract

Fifty-four evaluable patients with SCLC previously treated with chemotherapy received either N-methylformamide or spirogermanium. There was one partial response to N-methylformamide. The median survival times for patients treated with N-MF and spirogermanium were 11.7 and 12.6 weeks respectively. Five patients treated with N-MF experienced severe toxicity while four patients treated with spirogermanium experienced severe and life-threatening toxicity.

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References

    1. Proc Natl Acad Sci U S A. 1975 Mar;72(3):1003-6 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 May;75(5):2458-62 - PubMed
    1. Am J Clin Oncol. 1982 Dec;5(6):649-55 - PubMed

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