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. 2011 Jul;16(3):514-8.
doi: 10.1111/j.1369-1600.2010.00255.x. Epub 2010 Nov 4.

A genome-wide association study of DSM-IV cannabis dependence

Arpana Agrawal  1 , Michael T Lynskey, Anthony Hinrichs, Richard Grucza, Scott F Saccone, Robert Krueger, Rosalind Neuman, William Howells, Sherri Fisher, Louis Fox, Robert Cloninger, Danielle M Dick, Kimberly F Doheny, Howard J Edenberg, Alison M Goate, Victor Hesselbrock, Eric Johnson, John Kramer, Samuel Kuperman, John I Nurnberger Jr, Elizabeth Pugh, Marc Schuckit, Jay Tischfield; GENEVA Consortium; John P Rice, Kathleen K Bucholz, Laura J Bierut
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A genome-wide association study of DSM-IV cannabis dependence

Arpana Agrawal et al. Addict Biol. 2011 Jul.

Abstract

Despite twin studies showing that 50-70% of variation in DSM-IV cannabis dependence is attributable to heritable influences, little is known of specific genotypes that influence vulnerability to cannabis dependence. We conducted a genome-wide association study of DSM-IV cannabis dependence. Association analyses of 708 DSM-IV cannabis-dependent cases with 2346 cannabis-exposed non-dependent controls was conducted using logistic regression in PLINK. None of the 948 142 single nucleotide polymorphisms met genome-wide significance (P at E-8). The lowest P values were obtained for polymorphisms on chromosome 17 (rs1019238 and rs1431318, P values at E-7) in the ANKFN1 gene. While replication is required, this study represents an important first step toward clarifying the biological underpinnings of cannabis dependence.

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Figures

Figure 1
Figure 1
Manhattan plot showing genomewide association results for autosomal SNPs and SNPs on the X chromosome for DSM-IV cannabis dependence in SAGE.
See this image and copyright information in PMC

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