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Comment
. 2011 Jun 16;9(6):447-8.
doi: 10.1016/j.chom.2011.05.009.

KAPs off for HIV-1 integration

Anna Figueiredo  1 , Thomas J Hope
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KAPs off for HIV-1 integration

Anna Figueiredo et al. Cell Host Microbe. .
Free article

Abstract

Integration of reverse transcribed HIV-1 DNA into the host genome, catalyzed by HIV-1 integrase, represents an obligate step in establishing productive viral infection. Allouch et al. (2011) identify KAP1 (TRIM28) as an interaction partner of acetylated integrase. KAP1, in complex with HDAC1, represses HIV-1 integration through specific deacetylation of HIV-1 integrase.

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