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Review
. 2011 Oct;3(5):276-82.
doi: 10.1093/jmcb/mjr013. Epub 2011 Jun 13.

Applications of post-translational modifications of FoxO family proteins in biological functions

Ying Zhao  1 , Yachen Wang, Wei-Guo Zhu
Affiliations
Review

Applications of post-translational modifications of FoxO family proteins in biological functions

Ying Zhao et al. J Mol Cell Biol. 2011 Oct.

Abstract

The functions of the FoxO family proteins, in particular their transcriptional activities, are modulated by post-translational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, methylation and glycosylation. These PTMs occur in response to different cellular stresses, which in turn regulate the subcellular localization of FoxO family proteins, as well as their half-life, DNA binding, transcriptional activity and ability to interact with other cellular proteins. In this review, we summarize the role of PTMs of FoxO family proteins in linking their biological and functional relevance with various diseases.

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Comment in

  • Small changes for works.
    Wu J. Wu J. J Mol Cell Biol. 2011 Oct;3(5):269. doi: 10.1093/jmcb/mjr026. J Mol Cell Biol. 2011. PMID: 22028378 No abstract available.

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