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. 1990 Jul;34(7):1450-2.
doi: 10.1128/AAC.34.7.1450.

In vitro inhibition of bacterial DNA gyrase by cinodine, a glycocinnamoylspermidine antibiotic

M S Osburne  1 , W M Maiese, M Greenstein
Affiliations

In vitro inhibition of bacterial DNA gyrase by cinodine, a glycocinnamoylspermidine antibiotic

M S Osburne et al. Antimicrob Agents Chemother. 1990 Jul.

Abstract

Cinodine, a broad-spectrum glycocinnamoylspermidine antibiotic, binds to DNA and irreversibly inhibits bacterial and phase DNA synthesis. Cinodine was found to inhibit the activity of Micrococcus luteus DNA gyrase in vitro, but it did not inhibit the activities of two other DNA-binding enzymes, namely, topoisomerase I and BamHI. Although we cannot yet conclude that DNA gyrase is an intracellular target of the drug, in vitro inhibition of the enzyme by cinodine appears to be specific.

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References

    1. Proc Natl Acad Sci U S A. 1976 Dec;73(12):4474-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Nov;74(11):4767-71 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Nov;74(11):4772-6 - PubMed
    1. J Antibiot (Tokyo). 1978 May;31(5):398-404 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Oct;75(10):4838-42 - PubMed

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