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. 2011 May 25;13(3):309.
doi: 10.1186/bcr2871.

EZH2-mediated epigenetic repression of DNA repair in promoting breast tumor initiating cells

Olafur Andri Stefansson  1 , Manel Esteller
Affiliations

EZH2-mediated epigenetic repression of DNA repair in promoting breast tumor initiating cells

Olafur Andri Stefansson et al. Breast Cancer Res. .

Abstract

Members of the Polycomb-group (PcG) family of proteins, including EZH2 (enhancer of zeste homolog 2), are involved in establishing epigenetic silencing of developmental genes in adult and embryonic stem cells, and their deregulation has been implicated in cancer. In a recent report, EZH2-mediated epigenetic repression of DNA damage repair in breast tumor initiating cells (BTICs) was identified as a mechanism that could promote expansion of BTICs, and may contribute to cancer progression.

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