[A study on expression of Wnt signal pathway gene in familial aggregated hypertension]

Abstract

Objective: To determine the role of gene expression of Wnt signal pathway in the pathogenesis of familial aggregated hypertension.

Methods: The patients having directly related family members for more than three generations suffering from hypertension were enlisted in the hypertension group, and healthy individuals served as control group. The real-time polymerase chain reaction (PCR) gene array was used to detect the expression of functional classification genes of Wnt signal pathway in peripheral blood, with standard value deviated>2.0 from hypertension group/control group as differential genes.

Results: When hypertension group was compared with the control group, there were 6 differentially expressed genes, with 5 genes up-regulated, including Bcl-9, microphthalmia associated transcription factor (Mitf), secreted frizzled-related protein-1 (Sfrp-1), Wnt inhibiting factor-1 (Wif-1) and ribosomal protein-l13a (Rp-l13a). There was 1 gene down-regulated, i.e. dickkopf homolog-3 (Dkk-3).

Conclusion: The result of this study suggested that the Wnt signal pathway may be related to the occurrence and development of the familial aggregated hypertension.