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. 2011 Jul 15;204(2):274-81.
doi: 10.1093/infdis/jir261.

Role of a type IV-like secretion system of Streptococcus suis 2 in the development of streptococcal toxic shock syndrome

Yan Zhao  1 , Gaoke Liu, Shu Li, Min Wang, Jie Song, Jing Wang, Jiaqi Tang, Ming Li, Fuquan Hu
Affiliations

Role of a type IV-like secretion system of Streptococcus suis 2 in the development of streptococcal toxic shock syndrome

Yan Zhao et al. J Infect Dis. .

Abstract

Streptococcus suis serotype 2 (S. suis 2) has evolved into a highly invasive pathogen that was found to be the cause of 2 large-scale outbreaks of streptococcus toxic shock syndrome (STSS) in China. However, the mechanism of action of this non-group A streptococcal (GAS) S. suis-caused STSS is still unknown. Previously, we identified a unique pathogenicity island (PAI) designated 89K that is specific to the STSS-causing epidemic strains of S. suis 2. In this study, we further report a functional type IV-like secretion system (T4SS-like system) harbored in the 89K PAI that contributes to the development of STSS. Knockout of the 2 key components (VirD4-89K and VirB4-89K) of the T4SS-like system eliminated the lethality of the highly virulent strain and impaired its ability to trigger host immune response in experimental infection of mice. Our findings provide a new insight into the pathogenesis of STSS caused by the highly pathogenic S. suis 2 isolates.

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