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. 2011;9(5):832-843.
doi: 10.3390/md9050832. Epub 2011 May 12.

Three bianthraquinone derivatives from the mangrove endophytic fungus Alternaria sp. ZJ9-6B from the South China Sea

Cai-Huan Huang  1   2 , Jia-Hui Pan  1 , Bin Chen  1 , Miao Yu  2 , Hong-Bo Huang  1 , Xun Zhu  3 , Yong-Jun Lu  4 , Zhi-Gang She  1   3 , Yong-Cheng Lin  1   3
Affiliations

Three bianthraquinone derivatives from the mangrove endophytic fungus Alternaria sp. ZJ9-6B from the South China Sea

Cai-Huan Huang et al. Mar Drugs. 2011.

Abstract

Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea. Their structures were elucidated by one- and two-dimensional NMR spectroscopy, MS data analysis and circular dichroism measurements. Compounds 1, 2 and 3 were first isolated alterporriols with a C-2-C-2' linkage. The crystallographic data of tetrahydroaltersolanol B (7) was reported for the first time. In the primary bioassays, alterporriol K and L exhibited moderate cytotoxic activity towards MDA-MB-435 and MCF-7 cells with IC₅₀ values ranging from 13.1 to 29.1 μM.

Keywords: Alternaria sp.; alterporriol; bianthraquinone; cytotoxicity; endophytic fungus.

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Figures

Figure 1.
Figure 1.
Structures of 1–9 isolated from Alternaria sp. ZJ9-6B.
Figure 2.
Figure 2.
CD Spectra of 1. Recorded in MeOH at amibient temperature.
Figure 3.
Figure 3.
Key HMBC, NOE and 1H-1H COSY correlations of 1–3.
Figure 4.
Figure 4.
CD Spectra of 2 and 3. Recorded in MeOH at amibient temperature.
Figure 5.
Figure 5.
X-ray crystal structure of 7.
See this image and copyright information in PMC

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