Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Sep;14(9):801-9.

Benign fibrous histiocytoma of subcutaneous and deep soft tissue: a clinicopathologic analysis of 21 cases

Affiliations
  • PMID: 2167613

Benign fibrous histiocytoma of subcutaneous and deep soft tissue: a clinicopathologic analysis of 21 cases

C D Fletcher. Am J Surg Pathol. 1990 Sep.

Abstract

Twenty-one cases of benign fibrous histiocytoma arising in noncutaneous soft tissue are reported. These tumors presented most often in young to middle-aged adults with a predominance in males. They originated in deep subcutis (16 cases), skeletal muscle (three cases), and mesentery (two cases). The most common sites of incidence were the lower limb (eight cases) and head and neck region (six cases). Four of 12 cases with follow-up (median 3.0 years) recurred locally; all had originated in the subcutis. None metastasized. These lesions are generally larger and better circumscribed than their cutaneous counterparts. They are also usually more monomorphic and have a more consistent storiform pattern than the latter. A pericytomalike vascular pattern (six cases), xanthoma cells (six cases), and multinucleate giant cells (six cases) may be prominent. Hyaline or myxoid degeneration of the stroma is common. Rare features include small foci of necrosis and intravascular growth. Immunohistochemically, deep benign fibrous histiocytoma shows no evidence of true monocyte/macrophage differentiation and its histogenesis remains uncertain. The differential diagnosis includes malignant fibrous histiocytoma, dermatofibrosarcoma and hemangiopericytoma.

PubMed Disclaimer