Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2011 Aug 1;53(3):277-9.
doi: 10.1093/cid/cir400. Epub 2011 Jun 15.

Oseltamivir and risk of lower respiratory tract complications in patients with flu symptoms: a meta-analysis of eleven randomized clinical trials

Miguel A Hernán  1 , Marc Lipsitch
Affiliations
Meta-Analysis

Oseltamivir and risk of lower respiratory tract complications in patients with flu symptoms: a meta-analysis of eleven randomized clinical trials

Miguel A Hernán et al. Clin Infect Dis. .

Abstract

An independent reanalysis of 11 randomized clinical trials shows that oseltamivir treatment reduces the risk of lower respiratory tract complications requiring antibiotic treatment by 28% overall (95% confidence interval [CI], 11%-42%) and by 37% among patients with confirmed influenza infections (95% CI, 18%-52%).

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Oseltamivir and the risk of lower respiratory tract complications requiring antibiotics.
See this image and copyright information in PMC

Comment in

  • Does oseltamivir really reduce complications of influenza?
    Cochrane Neuraminidase Inhibitors Review Team. Cochrane Neuraminidase Inhibitors Review Team. Clin Infect Dis. 2011 Dec;53(12):1302-3; author reply 1303-4. doi: 10.1093/cid/cir706. Clin Infect Dis. 2011. PMID: 22080124 Free PMC article. No abstract available.

References

    1. Kaiser L, Wat C, Mills T, Mahoney P, Ward P, Hayden F. Impact of oseltamivir treatment on influenza-related lower respiratory tract complications and hospitalizations. Arch Intern Med. 2003;163:1667–72. - PubMed
    1. Jefferson T, Jones M, Doshi P, Del Mar C. Neuraminidase inhibitors for preventing and treating influenza in healthy adults: Systematic review and meta-analysis. BMJ. 2009;339:b5106. - PMC - PubMed
    1. Godlee F, Clarke M. Why don’t we have all the evidence on oseltamivir? BMJ. 2009;339:b5351. - PubMed
    1. Doshi P. Neuraminidase inhibitors—The story behind the Cochrane review. BMJ. 2009;339:b5164. - PubMed
    1. Cohen D. Complications: Tracking down the data on oseltamivir. BMJ. 2009;339:b5387. - PubMed

Publication types