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Comment
. 2011 Jun 15;474(7351):289-90.
doi: 10.1038/474289a.

Protein synthesis: Stop the nonsense

Adrian R Ferré-D'Amaré
Comment

Protein synthesis: Stop the nonsense

Adrian R Ferré-D'Amaré. Nature. .

Abstract

The amino acid sequence of proteins is specified by trinucleotides (codons), and their ends by one of three stop codons. A new study reveals how a subtle biochemical alteration can reprogram stop codons into amino acid-encoding codons at the messenger RNA (mRNA) level, without altering the DNA from which the mRNA is transcribed.

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Figures

Figure 1
Figure 1
Ψ synthases isomerize U into Ψ. Note the identical Watson-Crick faces of the two pyrimidine nucleotides. Thick line denotes the glycosidic bond.
See this image and copyright information in PMC

Comment on

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