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Case Reports
. 2011 Aug;83(8):1406-9.
doi: 10.1002/jmv.22109.

Positive Epstein-Barr virus and cytomegalovirus IgM assays in primary HIV infection

Jeffrey J Post  1 , Mun Khin Chan, L Ross Whybin, Qin Shi, William D Rawlinson, Philip Cunningham, Peter W Robertson
Affiliations
Case Reports

Positive Epstein-Barr virus and cytomegalovirus IgM assays in primary HIV infection

Jeffrey J Post et al. J Med Virol. 2011 Aug.

Abstract

We report three cases with misleading cytomegalovirus (CMV) or Epstein-Barr virus (EBV) immunoglobulin M (IgM) results during primary human immunodeficiency virus (HIV) infection. We determined the rate of positive anti-CMV IgM assays or anti-EBV capsid antigen IgM assays in sera from a group of well-characterized subjects with primary HIV infection as 2.9% (1/35; 95%CI: 0.15-16.6%) for each infection. The rate of positive anti-EBV capsid antigen IgM assays in subjects with positive hepatitis A virus IgM assays was 30% (6/20; 95%CI: 14.6-51.9%). Clinicians need to consider the limitations of IgM assays for diagnosis of herpesvirus infections, and consider testing for other infections with overlapping clinical manifestations.

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