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Clinical Trial
. 2011 Jul;52(7):1068-72.
doi: 10.2967/jnumed.110.085944. Epub 2011 Jun 16.

Mapping of lymphatic drainage from the prostate using filtered 99mTc-sulfur nanocolloid and SPECT/CT

Youngho Seo  1 , Carina Mari Aparici, Chien Peter Chen, Charles Hsu, Norbert Kased, Carole Schreck, Nick Costouros, Randall Hawkins, Katsuto Shinohara, Mack Roach Iii
Affiliations
Clinical Trial

Mapping of lymphatic drainage from the prostate using filtered 99mTc-sulfur nanocolloid and SPECT/CT

Youngho Seo et al. J Nucl Med. 2011 Jul.

Erratum in

  • J Nucl Med. 2013 Aug;54(8):1512

Abstract

We have developed a practice procedure for prostate lymphoscintigraphy using SPECT/CT and filtered (99m)Tc-sulfur nanocolloid, as an alternative to the proprietary product (99m)Tc-Nanocoll, which is not approved in the United States.

Methods: Ten patients were enrolled for this study, and all received radiotracer prepared using a 100-nm membrane filter at a commercial radiopharmacy. Whole-body scans and SPECT/CT studies were performed within 1.5-3 h after the radiotracer had been administered directly into 6 locations of the prostate gland under transrectal ultrasound guidance. The radiation dose was estimated from the first 3 patients. Lymphatic drainage mapping was performed, and lymph nodes were identified.

Results: The estimated radiation dose ranged from 3.9 to 5.2 mSv/MBq. The locations of lymph nodes draining the prostate gland were similar to those found using the proprietary product.

Conclusion: When the proprietary radiolabeled nanocolloid indicated for lymphoscintigraphy is not available, prostate lymph node mapping and identification are still feasible using filtered (99m)Tc-sulfur nanocolloid.

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Figures

Figure 1
Figure 1
Age distribution, radiotracer administration, identified lymph node locations, and representative coronal view of SPECT/CT for the patients enrolled for this study (patients 1–3).
Figure 2
Figure 2
Age distribution, radiotracer administration, identified lymph node locations, and representative coronal view of SPECT/CT for the patients enrolled for this study (patients 4–6)
Figure 3
Figure 3
Age distribution, radiotracer administration, identified lymph node locations, and representative coronal view of SPECT/CT for the patients enrolled for this study (patients 7–10)
See this image and copyright information in PMC

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