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. 1990 Jun;34(6):1271-2.
doi: 10.1128/AAC.34.6.1271.

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli

H Yoshida  1 , M Bogaki, M Nakamura, S Nakamura
Affiliations

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli

H Yoshida et al. Antimicrob Agents Chemother. 1990 Jun.

Abstract

Nucleotide sequence analysis of the gyrA genes of 10 spontaneous quinolone-resistant gyrA mutants of Escherichia coli KL16, including four mutants examined previously, disclosed that quinolone resistance was caused by a point mutation within the region between amino acids 67 and 106, especially in the vicinity of amino acid 83, of the GyrA protein.

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