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. 1990 Jun;34(6):1273-5.
doi: 10.1128/AAC.34.6.1273.

Proportion of DNA gyrase mutants among quinolone-resistant strains of Pseudomonas aeruginosa

H Yoshida  1 , M Nakamura, M Bogaki, S Nakamura
Affiliations

Proportion of DNA gyrase mutants among quinolone-resistant strains of Pseudomonas aeruginosa

H Yoshida et al. Antimicrob Agents Chemother. 1990 Jun.

Abstract

The proportion of DNA gyrase mutants among quinolone-resistant strains of Pseudomonas aeruginosa was examined by introducing the cloned wild-type Escherichia coli gyrA and gyrB genes. Of 101 spontaneous mutants of P. aeruginosa PAO505, 33 (33%) were found to have gyrA mutations. Among 17 clinical isolates, 12 (71%) had gyrA mutations and 1 (6%) had a gyrB mutation.

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