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. 2011 Aug;303(6):451-5.
doi: 10.1007/s00403-011-1159-3. Epub 2011 Jun 17.

Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients

Hideki Nakajima  1 , Kimiko Nakajima, Masahito Tarutani, Ryuji Morishige, Shigetoshi Sano
Affiliations

Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients

Hideki Nakajima et al. Arch Dermatol Res. 2011 Aug.

Abstract

Psoriasis is associated with an increase of Th17 cytokines, such as IL-17, IL-22, IL-21, and TNF-α, which are produced by Th17 cells. Adipokines are peptide hormones or cytokines secreted from adipose tissues and involved in the pathogenesis of metabolic syndrome (MS). Psoriasis patients have a high prevalence of the MS. In this study, we investigated the statistics of circulating Th17-related cytokines and adipokines in psoriasis patients. Our study identified the significant elevation of serum IL-6, IL-21, IL-22, and resistin levels in psoriasis patients. Increased serum levels of IL-22 and adiponectin were positively correlated with Psoriasis Area and Severity Index (PASI). In contrast, serum high molecular weight adiponectin levels were decreased in psoriasis and negatively correlated with PASI.

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Figures

Fig. 1
Fig. 1
Correlation between serum levels of cytokines and PASI score in psoriasis patients. Serum IL-21 levels did not positively correlate with PASI score in psoriasis patients (a). Serum IL-22 levels positively correlate with PASI score in psoriasis patients (b). Serum TNF-α levels did not positively correlate with PASI score in psoriasis patients (c)
Fig. 2
Fig. 2
Correlation between serum adipokine levels, PASI score, and BMI in psoriasis patients. Serum resistin levels did not positively correlate with PASI score (a). Correlation between serum levels of resistin and BMI in psoriasis patients (open circle), and normal controls (open triangle) (b). Serum resistin levels positively correlate with BMI in normal controls, although there was no positive correlation with BMI in psoriasis patients. Serum RBP-4 levels did not positively correlate with PASI score (c). There was no positive correlation between RBP-4 levels and BMI in psoriasis patients (d). Serum adiponectin levels positively correlated with PASI score in psoriasis patients (e). Serum adiponectin levels negatively correlate with BMI in normal controls, although there was slightly negative correlation in psoriasis patients (f)
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