Oral elastofibromatous lesions: a review and case series

Abstract

Elastofibromas of the oral cavity are rare, with only 5 cases reported. In this paper, we present a series of five new cases of oral elastofibromatous lesions, occurring in 4 males and 1 female, with ages ranging from 33 to 76 years. The clinical differential diagnosis includes fibroepithelial polyp or fibroma, among other connective tissue tumours. Elastofibromas probably develop as reactive lesions, for which surgical treatment is definitive.

Fig. 1

a Case 1: elastofibroma showing a raised nodular growth. (H&E stain; original magnification ×100; inset ×25). b Case 1: elastic fiber proliferation shown with MET stain (original magnification ×100; inset ×25)

Fig. 2

Case 2: proliferation of elastic fibers, resembling elastosis in many areas (H&E stain; original magnification ×400)

Fig. 3

a Case 3: This elastofibroma was described clinically as a “leukoplakia”, and shows an apparent raised area microscopically (H&E stain;. original magnification ×100; inset ×25). b Case 3: Elastic fiber proliferation shown with MET stain (original magnification ×100; inset ×25)

Fig. 4

Case 3: Globular and occasional “serrated edge” configuration of elastic fibers (H&E stain; original magnification ×400)

Fig. 5

Case 4: Elastic fibers dominated, showing a mostly globular arrangement (MET stain; original magnification ×400)