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. 2011 Aug 16;50(34):7862-4.
doi: 10.1002/anie.201102688. Epub 2011 Jun 16.

Total synthesis of synechoxanthin through iterative cross-coupling

Seiko Fujii  1 , Stephanie Y Chang, Martin D Burke
Affiliations
Free PMC article

Total synthesis of synechoxanthin through iterative cross-coupling

Seiko Fujii et al. Angew Chem Int Ed Engl. .
Free PMC article
No abstract available

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Figures

Figure 1
Figure 1
A) ICC with haloboronic acids in which the MIDA boronate serves as a masked boronic acid. B) A novel ICC strategy in which the polarity of the bifunctional building blocks is reversed and the MIDA boronate serves as a masked halide.
Scheme 1
Scheme 1
Retrosynthesis of 1 by ICC.
Scheme 2
Scheme 2
Synthesis of bisborylated diene 3.
Scheme 3
Scheme 3
Synthesis of key intermediate 11 by ICC. dppf = 1,1′-bis(diphenylphosphino)ferrocene.
Scheme 4
Scheme 4
Highly convergent assembly of synechoxanthin (1).
See this image and copyright information in PMC

References

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