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Review
. 2011 Aug;23(6):387-92.
doi: 10.1016/j.clon.2011.03.003. Epub 2011 Jun 16.

Mechanisms of cancer-induced bone pain

T Middlemiss  1 , B J A Laird, M T Fallon
Affiliations
Review

Mechanisms of cancer-induced bone pain

T Middlemiss et al. Clin Oncol (R Coll Radiol). 2011 Aug.

Abstract

Cancer-induced bone pain (CIBP) is common and challenging to treat. Common therapies, such as opioids, radiotherapy and bisphosphonates, are often only partially effective. CIBP is a different entity to inflammatory or neuropathic pain and needs to be considered as such. This overview examines the mechanisms of CIBP; the imbalance of bone turnover, peripheral and central nervous involvement and key neurochemical mediators. The current understanding of the underlying pathophysiology of CIBP is discussed.

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