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Review
. 2011 Sep;22(1):9-16.
doi: 10.1016/j.yebeh.2011.04.009. Epub 2011 Jun 17.

Cognitive and neurodevelopmental effects of antiepileptic drugs

Rebecca L Bromley  1 , Beth A Leeman, Gus A Baker, Kimford J Meador
Affiliations
Review

Cognitive and neurodevelopmental effects of antiepileptic drugs

Rebecca L Bromley et al. Epilepsy Behav. 2011 Sep.

Abstract

This article primarily represents the contributions of two young investigators to the understanding of the neuropsychological consequences of epilepsy and its treatment. The authors have reviewed two key areas of importance: the complex relationship between cognitive dysfunction and epilepsy and the risks of cognitive dysfunction in children as a consequence of in utero exposure to antiepileptic drug treatment. The work of two young investigators is presented and future research needs are outlined.

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Figures

Fig. 1.
Fig. 1.
Study methodologies employed to investigate in utero exposure to AEDs over the last three decades. Republished with permission [6].
See this image and copyright information in PMC

References

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    1. Hill RM, Tennyson LM. Significant anomalies in the antiepileptic drug syndrome: comment. In: Janz D, Dam M, Richens A, Bossi L, Helge H, Schmidt D, editors. Epilepsy, pregnancy and the child New York: Raven Press; 1982. p. 309–11.
    1. Bromley RL. Foetal exposure to antiepileptic drugs: cognitive outcomes in the child Thesis, University of Liverpool; 2009.
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    1. Speidel BD, Meadow SR. Maternal epilepsy and abnormalities of the fetus and newborn. Lancet 1972;21:839–41. - PubMed

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