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Review
. 2011 Sep;301(3):H647-53.
doi: 10.1152/ajpheart.01271.2010. Epub 2011 Jun 17.

ROS-induced ROS release in vascular biology: redox-redox signaling

Natalya S Zinkevich  1 , David D Gutterman
Affiliations
Review

ROS-induced ROS release in vascular biology: redox-redox signaling

Natalya S Zinkevich et al. Am J Physiol Heart Circ Physiol. 2011 Sep.

Abstract

The involvement of reactive oxygen species (ROS) in regulating vascular function both in normal vessels and as part of an adaptive response during disease has been intensively studied. From the recognition that ROS serve as important signaling molecules has emerged multiple lines of evidence that there is a functional connectivity between intracellular sites of ROS production. This cross talk has been termed ROS-induced ROS release (RIRR) and is supported by a variety of observations showing that RIRR is a common mechanism for ROS amplification and regional ROS generation. The compartmentalization of ROS production within a cell is critical to its signaling function and is facilitated by microlocalization of specific scavengers. This review will provide descriptions and examples of important mechanisms of RIRR.

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Figures

Fig. 1.
Fig. 1.
A–D: sequence of events illustrating direct reactive oxygen species (ROS)-induced ROS release (RIRR). O2·−, superoxide; H2O2, hydrogen peroxide.
Fig. 2.
Fig. 2.
A–D: sequence of events illustrating complex RIRR. ONOO−, peroxynitrite; NO, nitric oxide; eNOS, endothelial NO synthase.
See this image and copyright information in PMC

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