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. 2011 Jan;1(1):6-11.
doi: 10.4161/cl.1.1.14693.

A brief history of the cisternal progression-maturation model

Alberto Luini  1
Affiliations

A brief history of the cisternal progression-maturation model

Alberto Luini. Cell Logist. 2011 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Transport by cisternal progression. Cargo proteins leave the ER within dissociative carriers that reach the cis face of the Golgi stack, where these carriers coalesce to form a new cis-Golgi cisterna. At the same time, the trans-most Golgi cisterna (in this case, identifiable with the TGN) disassembles into transport carriers that are directed towards the plasma membrane. The process continues: new cis cisternae form, and old cisternae disassemble; as a result, each cisterna changes its position in the stack—repeatedly—until it reaches the trans face.
Figure 2
Figure 2
Transport by cisternal progression-maturation. Cargo proteins leave the ER within dissociative carriers that reach the cis face of the Golgi stack, where these carriers coalesce and receive cis-Golgi enzymes that recycle from the cis cisterna, forming a new cis cisterna in the process. Subsequently, this cis cisterna receives medial-Golgi components from the medial cisterna and loses its cis components to a new forming cis cisterna. This changes its composition and it matures into a medial cisterna, and it also progresses to a medial position in the Golgi stack. This maturation process repeats itself until the original cis cisterna, now matured into a trans-Golgi network element and located at the trans-Golgi face, recycles its resident enzymes back to the underlying trans cisterna and breaks down into cargo-laden carriers, which move to the plasma membrane.
Figure 3
Figure 3
Transport by a modified cisternal progression-maturation mechanism. This mechanism is identical to cisternal maturation-progression, except that the maturation ends at the trans-Golgi level, rather than at the trans-Golgi network (TGN). Then, the trans-Golgi element recycles its resident enzymes back to the underlying cisterna and breaks down into cargo-laden carriers, which move to and accumulate in, the TGN. This modification to the cisternal maturation-progression model accommodates data indicating a mono-exponential rate of export from the TGN.
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