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. 2009:2009:bcr08.2008.0757.
doi: 10.1136/bcr.08.2008.0757. Epub 2009 Mar 17.

Diffuse alveolar haemorrhage secondary to warfarin therapy for atrial fibrillation: a case report and literature review

Abdelkarim Waness  1 , Tarek Aldabbagh, Mohammed Harakati
Affiliations

Diffuse alveolar haemorrhage secondary to warfarin therapy for atrial fibrillation: a case report and literature review

Abdelkarim Waness et al. BMJ Case Rep. 2009.

Abstract

Alveolar haemorrhage is a rare and serious medical emergency with many causes. Diffuse alveolar haemorrhage due to warfarin therapy has been rarely reported in the literature. In this paper, we describe the case of 62-year-old woman with a history of chronic atrial fibrillation treated with warfarin, who was admitted to our institution with haemoptysis and dyspnoea. Alveolar haemorrhage was suspected clinically and subsequently confirmed by bronchoscopy. The patient required aggressive treatment with fresh frozen plasma, vitamin K and mechanical ventilation with a successful outcome. We emphasise the need for early diagnosis and fast therapeutic intervention, especially with over-anticoagulation (INR >9), in patients with this rare and potentially lethal condition.

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Figures

Figure 1
Figure 1
Chest x ray on admission.
Figure 2
Figure 2
Computed tomography of the chest on admission.
Figure 3
Figure 3
CT of the chest 7 weeks after admission.
See this image and copyright information in PMC

References

    1. Green RJ, Ruoss SJ, Kraft SA, et al. Pulmonary capillaritis and alveolar hemorrhage. Update on diagnosis and management. Chest 1996; 110: 1305–16 - PubMed
    1. Clutterbuck EJ, Pusey CD. Severe alveolar hemorrhage in Churg-Strauss syndrome. Eur J Respir Dis 1987; 71: 158–63 - PubMed
    1. Marci A, Stoica R, Ion I, et al. [Wegener granulomatosis with severe alveolar hemorrhagic syndrome] (in Romanian). Pneumologia 2007; 56: 137–41 - PubMed
    1. Santos BH, Santos RR, Santos CF, et al. Pulmonary hemorrhage as a manifestation of systemic lupus erythematosus. Rev Hosp Clin Fac Med Sao Paulo 2004; 59: 47–50 - PubMed
    1. Kronauer CM, Keusch G, Burger HR, et al. [Alveolar hemorrhage] (in German). Schweiz Med Wochenschr 1989; 119: 1454–65 - PubMed

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