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. 1990 Jun;40(6):693-7.

Antiinflammatory properties of the new antirheumatic agent 4-acetylaminophenylacetic acid

H Fujisawa  1 , T Nishimura, Y Inoue, S Ogaya, Y Shibata, Y Nakagawa, S Sato, K Kimura
Affiliations
  • PMID: 2168705

Antiinflammatory properties of the new antirheumatic agent 4-acetylaminophenylacetic acid

H Fujisawa et al. Arzneimittelforschung. 1990 Jun.

Erratum in

  • Arzneimittelforschung 1990 Oct;40(10):1172

Abstract

The antiinflammatory activity of 4-acetylaminophenylacetic acid (MS-932) was investigated. MS-932 did not suppress the acute inflammation of carrageenin-induced paw edema in rats or of primary swelling in adjuvant arthritic rats. However, prophylactic treatment with MS-932 inhibited secondary inflammation in adjuvant arthritic rats. MS-932 also restored to normal the weight of the spleen and the serum albumin/globulin ratio of adjuvant arthritic rats. In addition to its prophylactic effect, MS-932 had a therapeutic effect on adjuvant arthritis. In in vitro tests, MS-932 did not inhibit prostaglandin E2 biosynthesis from arachidonic acid by sheep seminal vesicle microsomal enzyme or superoxide generation by guinea pig neutrophils stimulated with opsonized zymosan. MS-932 had no analgesic effect in mice and no antipyretic effect in rats. These results indicate that MS-932 suppresses adjuvant arthritis through modulation of the immune system.

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