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. 2011:2011:854142.
doi: 10.1155/2011/854142. Epub 2011 May 29.

Positive fluid balance is associated with higher mortality and prolonged mechanical ventilation in pediatric patients with acute lung injury

Heidi R Flori  1 , Gwynne Church, Kathleen D Liu, Ginny Gildengorin, Michael A Matthay
Affiliations

Positive fluid balance is associated with higher mortality and prolonged mechanical ventilation in pediatric patients with acute lung injury

Heidi R Flori et al. Crit Care Res Pract. 2011.

Abstract

Introduction. We analyzed a database of 320 pediatric patients with acute lung injury (ALI), to test the hypothesis that positive fluid balance is associated with worse clinical outcomes in children with ALI. Methods. This is a post-hoc analysis of previously collected data. Cumulative fluid balance was analyzed in ml per kilogram per day for the first 72 hours after ALI while in the PICU. The primary outcome was mortality; the secondary outcome was ventilator-free days. Results. Positive fluid balance (in increments of 10 mL/kg/24 h) was associated with a significant increase in both mortality and prolonged duration of mechanical ventilation, independent of the presence of multiple organ system failure and the extent of oxygenation defect. These relationships remained unchanged when the subgroup of patients with septic shock (n = 39) were excluded. Conclusions. Persistently positive fluid balance may be deleterious to pediatric patients with ALI. A confirmatory, prospective randomized controlled trial of fluid management in pediatric patients with ALI is warranted.

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Figures

Figure 1
Figure 1
Bar graph depicting the association between cumulative fluid balance within the first 72 hours after ALI and all-cause mortality.
Figure 2
Figure 2
Bar graph depicting the association between cumulative fluid balance within the first 72 hours after ALI and need for prolonged mechanical ventilation (patients requiring mechanical ventilation for ≥14 days).
See this image and copyright information in PMC

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