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. 2011:2011:656013.
doi: 10.1155/2011/656013. Epub 2011 May 2.

Neutropenia and Neutropenic Complications in ABVD Chemotherapy for Hodgkin Lymphoma

Bhanu Vakkalanka  1 , Brian K Link
Affiliations

Neutropenia and Neutropenic Complications in ABVD Chemotherapy for Hodgkin Lymphoma

Bhanu Vakkalanka et al. Adv Hematol. 2011.

Abstract

A combination of Adriamycin (a.k.a. Doxorubicin), Bleomycin, Vinblastine, and Dacarbazine (ABVD) is the most commonly used chemotherapy regime for Hodgkin lymphoma. This highly effective treatment is associated with a significant risk of neutropenia. Various strategies are adopted to counter this commonly encountered problem, including dose modification, use of colony stimulating factors, and prophylactic or therapeutic use of antibiotics. Data to support these approaches is somewhat controversial, and in keeping with the paucity of definitive evidence, there is a wide disparity in the management of neutropenia in patients receiving ABVD chemotherapy. This paper summarizes the evidence for managing ABVD-related neutropenia during the treatment of Hodgkin lymphoma.

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References

    1. Caporaso NE, Goldin LR, Anderson WF, Landgren O. Current insight on trends, causes, and mechanisms of Hodgkin’s lymphoma. Cancer Journal. 2009;15(2):117–123. - PubMed
    1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. Ca-A Cancer Journal for Clinicians. 2005;55(2):74–108. - PubMed
    1. Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 1994;84(5):1361–1392. - PubMed
    1. Lister TA, Crowther D, Sutcliffe SB, et al. Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin’s disease: cotswolds meeting. Journal of Clinical Oncology. 1989;7(11):1630–1636. - PubMed
    1. Fermé C, Eghbali H, Meerwaldt JH, et al. Chemotherapy plus involved-field radiation in early-stage Hodgkin’s disease. New England Journal of Medicine. 2007;357(19):1916–1927. - PubMed

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