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. 2008 May 5;20(9):1630-1635.
doi: 10.1002/adma.200800004.

Magnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging

Ji-Ho Park  1 , Geoffrey von Maltzahn, Lianglin Zhang, Michael P Schwartz, Erkki Ruoslahti, Sangeeta N Bhatia, Michael J Sailor
Affiliations

Magnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging

Ji-Ho Park et al. Adv Mater. .
No abstract available

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Figures

Figure 1
Figure 1
Physical properties of magnetic NWs and conventional spherical nanoparticles (nanospheres; NSs) preparations. a) TEM image showing the wormlike nanostructure. More than 80% of the particles have a contorted linear appearance with a hydrodynamic length of 50–80 nm. Scale bar is 30 nm. (Inset: atomic force microscopy image showing the elongated shape. Scale bar is 100 nm). b) Magnetization curves for NWs, NSs, and Feridex. c) T2 relaxation rates as a function of iron concentration (mm Fe) for NWs, NSs, and Feridex. d) T2-weighted MR images of NWs, NSs, and Feridex with different concentrations.
Figure 2
Figure 2
Internalization of nanoworms (NWs) and nanospheres (NSs) conjugated with F3 peptides into MDA-MB-435 cells. a) Conceptual scheme illustrating the increased multivalent interactions expected between receptors on a cell surface and targeting ligands on a NW compared with a NS. b) Fluorescence data comparing the efficiency of cellular internalization for various functionalized NW and NS systems. NH2, F3, and PEG-F3 indicate aminated NW/NS, F3-conjugated NW/NS and PEGylgated F3-conjugated NW/NS, respectively. c) Fluorescence microscope images of cells 3 h after incubation with F3(FITC)-conjugated NW (NW-175-F) or F3(FITC)-conjugated NS (NS-30-F) (green). Nuclei are visualized with a DAPI stain (blue). Scale bar is 20 µm.
Figure 3
Figure 3
In vivo behavior of untargeted nanoworms (NWs) in the mouse. a) Percentage of NW remaining in circulation as a function of time with an injection dose (ID) of 3 mgFe kg−1. The solid line represents an exponential fit. b) Biodistribution of NW 24 h post injection. Bl, blood; Br, brain; H, heart; K, kidneys; Li, liver; Lu, lungs; LN, lymph node; Sk, skin; and Sp, spleen. c) Fluorescence images of mice bearing MDA-MB-435 tumors, obtained 6, 24, and 48 h after injection of NW or NS with an ID of 1 mg Fe kg−1. Arrows and arrowheads point to the tumors and the livers, respectively.
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References

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