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Randomized Controlled Trial
. 2012 Jun;18(6):1018-25.
doi: 10.1002/ibd.21795. Epub 2011 Jun 17.

Randomized, controlled trial of home telemanagement in patients with ulcerative colitis (UC HAT)

Raymond K Cross  1 , Nadia Cheevers, Ankur Rustgi, Patricia Langenberg, Joseph Finkelstein
Affiliations
Randomized Controlled Trial

Randomized, controlled trial of home telemanagement in patients with ulcerative colitis (UC HAT)

Raymond K Cross et al. Inflamm Bowel Dis. 2012 Jun.

Abstract

Background: Outcomes are suboptimal in ulcerative colitis (UC). Telemedicine for UC is feasible and improves outcomes. Our goals were to evaluate a home telemanagement system for UC (UC HAT) on disease activity, quality of life (QoL), and adherence compared to best available care (BAC) in a randomized, controlled trial.

Methods: Adults with UC were randomly assigned to receive UC HAT or BAC for 12 months. UC HAT recruits answered questions regarding disease activity, adherence, side effects, and measured their weight weekly. An educational curriculum was delivered after each session. Alerts and action plans were generated based on the results. BAC underwent routine follow-up, received written action plans, and were given educational fact sheets. Seo Index scores, Inflammatory Bowel Disease Questionnaire (IBDQ) scores, and adherence rates were compared between UC HAT and BAC at 1 year.

Results: Twenty-five patients were randomized to UC HAT and 22 to BAC. After 12 months, 11 withdrew in UC HAT compared to 5 in BAC. Disease activity, QoL, and adherence were not different between groups at any timepoint postbaseline. Adjusted analyses of trial completers using all available data demonstrated decreased Seo Index (11.9 in UC HAT (P = 0.08) versus 1.2 in BAC (P = 0.84) and increased IBDQ scores (12.5 in UC HAT (P = 0.04) versus to -3.8 in BAC (P = 0.47) from baseline in UC HAT compared to BAC.

Conclusions: UC HAT did not improve disease activity, QoL, or adherence compared to BAC after 1 year. After adjustment for baseline disease knowledge, UC HAT trial completers experienced significant gains in disease-specific QoL from baseline compared to BAC trial completers. Our results suggest a potential benefit of UC HAT. Further research is indicated to determine if telemedicine improves outcomes in patients with IBD.

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Figures

Figure 1
Figure 1
The Home Telemanagement System for Patients with Ulcerative Colitis (UC HAT). UC HAT is comprised of a home unit (laptop computer and electronic weight scale) and web portal.
Figure 2
Figure 2
Participant Flow in the Home Telemanagement for Patients with Ulcerative Colitis Trial
Figure 3
Figure 3
Difference in IBDQ Scores from baseline to the 12 month visit between the UC HAT and BAC Arms in the Home Telemanagement for Patients with Ulcerative Colitis Trial. UC HAT=home telemanagement, BAC=Best Available Care. Groups were compared using repeated measures linear regression. Analyses shown are per protocol analyses.
See this image and copyright information in PMC

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